Quinazolin-4-(3H)-one is a versatile lead molecule for the design of potential bioactive agents. The molecular manipulation of a promising lead compound is still a major line of approach for the discovery of new drugs. There has been considerable interest in the development of novel compounds with antibacterial, antifungal, anti-HIV, CNS depressant, antitubercular, anticancer, antioxidant, analgesic, anti-inflammatory, anticonvulsant and antiviral activities. SAR studies have indicated that substitution at position 2 and 3 can modulate activities of the molecule. Therefore many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observation shave been the guiding for the development for new quinazolinones that possesses varied biological activities.
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